| Pair Name | Cryptotanshinone, Temozolomide | ||
| Phytochemical Name | Cryptotanshinone (PubChem CID: 160254 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Cryptotanshinone, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| Down-regulation | Expression | MGMT | hsa4255 | |
| Up-regulation | Expression | H2AX | hsa3014 | |
| In Vitro Model | LN-229 | Glioblastoma | Homo sapiens (Human) | CVCL_0393 |
| U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 | |
| Result | Combined treatment with CTS and TMZ might be an effective option to overcome the chemoresistance of GBM cells in a long-term treatment strategy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells. Sci Rep. 2023 Dec 9;13(1):21835. doi: 10.1038/s41598-023-48777-z. | Click |
